منابع مشابه
MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7
We recently reported that miR-224 was significantly up-regulated in non-small cell lung cancer (NSCLC) tissues, in particular in resected NSCLC metastasis. We further demonstrated that miR-224 functions as an oncogene in NSCLC by directly targeting TNFAIP1 and SMAD4. However, the biological functions of miR-224 in NSCLC are controversial and underlying mechanisms of miR-224 in the progression a...
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BACKGROUND Since 1910, a variety of radiation modalities, including radioactive isotopes, photons, and particle beams, have been used to treat prostatic cancer. METHODS This report focuses on external beam x-irradiation produced by medium energy linear accelerators. Between 1956 and 1990, 1119 patients have been treated with curative intent at Stanford University. Tumor doses of 70 Gy deliver...
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Caspase-3, caspase-7, and caspase-8 are important caspases in the apoptosis pathway and play an important role in the development and progression of cancer. We examined the association between genetic variants in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer among Chinese women. Genotypes for 1,028 women with endometrial cancer and 1,003 healthy controls were det...
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Telemedicine has had a positive impact on some aspects of patient care. However, existing telemedicine systems that use high-quality video are inflexible, requiring investment in fixed infrastructure. We have overcome a number of technical challenges to build a mobile telemedicine system that can reliably deliver high-quality video from both stationary sites and moving vehicles. Our system is c...
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We studied the molecular mechanisms of apoptosis in the prostate cancer cell line LNCaP and whether overexpression of caspase activity could force this cell line to undergo apoptosis. The inhibitor of phosphomevalonate decarboxylase, sodium phenylacetate, and the protein kinase inhibitor staurosporine induced (a) release of cytochrome c from the mitochondria to the cytosol; (b) reduction in mit...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2013
ISSN: 0021-9738
DOI: 10.1172/jci71440